
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Evaluating the occupation-related harm to the health of ore mining workers using target protein analysis
1 Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for the Oversight of Consumer Protection and Welfare, Perm, Russia
2 Regional Office of the Federal Service for the Oversight of Consumer Protection and Welfare of the Russian Federation for Krasnoyarsky Krai, Krasnoyarsk, Russia
3 Perm State National Research University, Perm, Russia
4 Russian Academy of Sciences, Moscow, Russia
5 Regional Clinical Hospital, Krasnoyarsk, Russia
Correspondence should be addressed: Marina A. Zemlyanova
Monastyrskaya, 82, Perm, 614045, Russia; ur.ksircf@mez
Funding: the study was carried out at the expense of the federal budget as part of a state assignment for the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for the Oversight of Consumer Protection and Welfare of the Russian Federation.
Acknowledgement: the authors express their gratitude to the staff of the Occupational pathology Department of the Regional Center for Occupational Pathology of the Krasnoyarsk Regional Clinical Hospital for their assistance in organizing and conducting research by the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies (Department of Biochemical and Cytogenetic Research Methods).
Author contribution: Zaitseva NV — editing; Fadeev AG, Goryaev DV, Zemlyanova MA — study concept and design, editing; Peskova EV — study concept and design, literature data acquisition, manuscript writing; Bulatova NI, Galiulina AV, Zakharinskaya ON — data processing; all authors — approval of final version of the article, responsibility for consistency of all parts of the article.
Compliance with ethical standards: the study involved employees of a mining facility (copper-nickel production); it was conducted in accordance with international standards of medical practice (Declaration of Helsinki, revision of 2013, 2024) and approved by the Ethics Committee of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies (Minutes No. 4 of February 24, 2022).
- Fadeev AG, Gorjaev DV, Shur PZ, Zajceva NV, Fokin VA, Redko SV. Vrednye veshhestva v vozduhe rabochej zony gornodobyvajushhego sektora metallurgicheskoj promyshlennosti kak faktory riska dlja zdorov'ja rabotnikov (analiticheskij obzor). Analiz riska zdorov'ju. 2024; (2): 153–61 (in Rus.). DOI: 10.21668/health.risk/2024.2.14.
- Izmerov NF, redaktor. Professional'naja patologija: nacional'noe rukovodstvo. M.: GJeOTAR-Media, 2011; 784 p. (in Rus.).
- Izmerov NF, redaktor. Rossijskaja jenciklopedija po medicine truda. M.: Medicina, 2005; 653 p. (in Rus.).
- Ushakov KZ, Kaledina NO, Kirin BF, Srebnyj M., Dikolenko EJa, Ilin AM, et al. Bezopasnost' vedenija gornyh rabot i gornospasatel'noe delo. M.: Izdatel'stvo Moskovskogo gosudarstvennogo gornogo universiteta, 2002; 487 p. (in Rus.).
- Naota M, Shimada A, Morita T, Inoue K, Takano H. Translocation pathway of the intratracheally instilled C60 fullerene from the lung into the blood circulation in the mouse: possible association of diffusion and caveolae-mediated pinocytosis. Toxicol Pathol. 2009; 37 (4): 456–62. DOI: 10.1177/0192623309335059.
- Qiu J, Ma J, Dong Z, Ren Q, Shan Q, Liu J. Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution. Nat Commun. 2024; 15 (1): 7396. DOI: 10.1038/s41467-024-51686-y.
- Liu X, Wei W, Liu Z, Song E, Lou J, Feng L, et al. Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage. Proc Natl Acad Sci USA. 2021; 118 (44): e2108131118. DOI: 10.1073/pnas.2108131118.
- Qi Y, Wei S, Xin T, Huang C, Pu Y, Ma J, et al. Passage of exogeneous fine particles from the lung into the brain in humans and animals. Proc Natl Acad Sci USA. 2022; 119 (26): e2117083119. DOI: 10.1073/pnas.2117083119.
- Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, et al. The next generation of risk assessment multi-year study-highlights of findings, applications to risk assessment, and future directions. Environ Health Perspect. 2016; 124 (11): 1671–682. DOI: 10.1289/EHP233.
- Van Summeren A, Renes J, van Delft JH, Kleinjans JC, Mariman EC. Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity. Toxicol In Vitro. 2012; 26 (3): 373–85. DOI: 10.1016/j.tiv.2012.01.012.
- Zajceva NV, Zemljanova MA, Dolgih OV. Genomnye, transkriptomnye i proteomnye tehnologii kak sovremennyj instrument diagnostiki narushenij zdorov'ja, associirovannyh s vozdejstviem faktorov okruzhajushhej sredy. Gigiena i sanitarija. 2020; 99 (1): 6–12 (in Rus.). DOI: 10.47470/0016-9900-2020-99-1-6-12.
- Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002; 1 (11): 845–67. DOI: 10.1074/mcp.r200007-mcp200.
- Corzett TH, Fodor IK, Choi MW, Walsworth VL, Turteltaub KW, McCutchen-Maloney SL, et al. Statistical analysis of variation in the human plasma proteome. J Biomed Biotechnol. 2010; (2010): 258494. DOI: 10.1155/2010/258494.
- El Safty AMK, Samir AM, Mekkawy MK, Fouad MM. Genotoxic effects due to exposure to chromium and nickel among electroplating workers. Int J Toxicol. 2018; 37 (3): 234–40. DOI: 10.1177/1091581818764084.
- Durkin JT, Holskin BP, Kopec KK, Reed MS, Spais CM, Steffy BM, et al. Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop. Biochemistry. 2004; 43 (51): 16348–55. DOI: 10.1021/bi049866y.
- Stavusis J, Micule I, Grinfelde I, Zdanovica A, Pudulis J, Valeina S, et al. Altered splicing of LAMP2 in a multigenerational family from Latvia affected by Danon disease. Medicina (Kaunas). 2024; 60 (1): 99. DOI: 10.3390/medicina60010099.
- Xu P, Liu A, Li F, Tinkov AA, Liu L, Zhou JC. Associations between metabolic syndrome and four heavy metals: a systematic review and meta-analysis. Environ Pollut. 2021; (273): 116480. DOI: 10.1016/j.envpol.2021.116480.
- Shraideh Z, Badran D, Hunaiti A, Battah A. Association between occupational lead exposure and plasma levels of selected oxidative stress related parameters in Jordanian automobile workers. Int J Occup Med Environ Health. 2018; 31 (4): 517–25. DOI: 10.13075/ijomeh.1896.01243.
- Tsoukas MA, Mantzoros CS. Lipodystrophy syndromes. In: Endocrinology: adult and pediatric. 2016; 648–61.e5. DOI: 10.1016/B978-0-323-18907-1.00037-8.
- Leren TP. Sorting an LDL receptor with bound PCSK9 to intracellular degradation. Atherosclerosis. 2014; 237 (1): 76–81. DOI: 10.1016/j.atherosclerosis.2014.08.038.
- Hsieh J, Koseki M, Molusky MM, Yakushiji E, Ichi I, Westerterp M, et al. TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature. 2016; 535 (7611): 303–7. DOI: 10.1038/nature18628.
- Tominaga K, Johmura Y, Nishizuka M, Imagawa M. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. J Cell Sci. 2004; 117 (Pt 25): 6217–26. DOI: 10.1242/jcs.01546.
- Romancova TI. Zhirovaja tkan': cveta, depo i funkcii. Ozhirenie i metabolizm. 2021; 18 (3): 282–301 (in Rus.). DOI: 10.14341/omet12748.
- Sjurin SA, Shilov VV. Osobennosti narushenij zdorov'ja gornjakov severnyh medno-nikelevyh rudnikov. Gigiena i sanitarija. 2016, 95 (5); 455–9 (in Rus.). DOI: 10.18821/0016-9900-2016-95-5-455-459.
- Xia R, Wang N, Xu Z, Lu Y, Song J, Zhang A, et al. Cryo-EM structure of the human histamine H1 receptor/Gq complex. Nat Commun. 2021; 12 (1): 2086. DOI: 10.1038/s41467-021-22427-2.
- Buelow M, Süßmuth D, Smith LD, Aryani O, Castiglioni C, Stenzel W, et al. Novel bi-allelic variants expand the SPTBN4-related genetic and phenotypic spectrum. Eur J Hum Genet. 2021; 29 (7): 1121–8. DOI: 10.1038/s41431-021-00846-5.
- Davis DM. The compatibility gene: how our bodies fight disease, attract others, and define our selves. Oxford: Oxford University Press, 2014; 256 p.
- Brucato N, Guadalupe T, Franke B, Fisher SE, Francks C. A schizophrenia-associated HLA locus affects thalamus volume and asymmetry. Brain Behav Immun. 2015; (46): 311–8. DOI: 10.1016/j.bbi.2015.02.021.