ISSN Print 2713-0878    ISSN Online 2713-0886
Russian Bulletin of Hygiene
BIOMEDICAL JOURNAL OF ERMC EASTERN EUROPEAN

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Original research Assessing toxicity and hazard of agidol-1, the vitamin E synthetic analogue
Golubeva MI, Sheina NI, Bidevkina MV, Bobrineva IA, Fedorova EA
Agidol-1 belongs to non-enzymatic antioxidants and represents a synthetic vitamin E analogue, it is widely used in chemical and food industries, livestock production, cosmetology, perfumery and pharmaceutical production. The increase in its production is a prerequisite for creating optimal working conditions for employees and developing the currently not existing hygienic standard of the tentative safe exposure level (OBUV) in workplace air. The study aimed to develop and substantiate agidol-1 OBUV in workplace air through experimental study of toxicity and hazard. We studied toxicity, irritant, skin-resorptive effects and hazard of agidol-1 concentrations of 24.7 and 67.8 mg/m3 after a single inhalation. Integrated indicators and functional indicators of some organs and systems were assessed in rats after inhalation. It has been shown that based on toxicometry data (DL50) after a single intragastric injection to mice agidol-1 is a moderately dangerous substance (hazard class 3), while when administered to rats it is a slightly dangerous substance (hazard class 4). The substance has no irritant effect on the rabbit ocular mucosa and skin, it does not possess skin-resorptive or cumulative activity. Inhalation of agidol-1 concentrations of 24.7 and 67.8 mg/m3 has no toxic effect on the nervous, carviovascular, and respiratory systems, it does not alter peripheral blood composition and biochemical parameters of blood serum and urine. The lack of agidol-1 harmful effects in the study, availability of MPC levels in ambient air for the Agidol brand substances with the chemical composition similar to that of agidol-1 and hygienic standards for agidol-1 in different countries have made it possible to substantiate OBUV for production facilities of 10 mg/m3, aerosol, hazard class 4.
Received: 2024-09-01
Published online: 2025-03-30
DOI: 10.24075/rbh.2025.125
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VIEWS 293
Opinion The strategy for scientific support in implementing state policy on optimizing population nutrition
Tutelyan VA, Nikityuk DB, Tarmayeva IYu, Pogozheva AV
The article presents the authors' opinion on ways to optimize the nutrition of the population of the Russian Federation. It shows that the dietary patterns currently common in the country are still far from optimal, as they underdeliver on vegetables, fruits, and dairy products, and provide excessive amounts of sugar, salt, foods rich in animal fat, and trans fats. Inadequate dietary patterns compromise health and nutritional status, leading to an increase in diet-related diseases such as cancer, cardiovascular diseases, type 2 diabetes, obesity, gout, and osteoporosis, which are major contributors to mortality in economically developed countries, including Russia. According to the authors, there are several aspects that are crucial in the matter of overall health improvement and extension of active longevity: optimization of the dietary patterns in Russia, popularization of the principles of rational nutrition and healthy lifestyle; introduction of measures to decrease the incidence of socially significant non-communicable diseases (atherosclerosis, cardiovascular diseases, hypertension, type 2 diabetes mellitus, nutritional obesity, and others); acceleration of adoption of innovative health protection technologies in healthcare, including early diagnosis of non-communicable diseases of an alimentary nature, their targeted prevention and treatment.
Received: 2025-01-28
Published online: 2025-03-29
DOI: 10.24075/rbh.2025.124
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VIEWS 545
Original research Analysis of body mass index formation in children and adolescents of the Russian Federation
Levushkin SP, Milushkina OYu, Skoblina NA, Markelova SV, Tatarinchik AA, Ivanov MS
To prevent health problems in pediatric population, the Russian Federation (RF) is implementing the Complex of measures to combat obesity in children under 18 years of age, approved on  December 1, 2023, No. 18824-P12-TG. The study aimed to consider body mass index (BMI) formation in Russian children and adolescents in the regional aspect. As part of the all-Russian monitoring of the physical development of children and adolescents in 2021–2024, BMI of 258,611 boys and 252,629 girls living in 50 constituent entities of the RF was studied. Big data analysis has shown that in most regions there is a harmonious development of the child population and the indicators fit into the BMI 25th–75th centile for the RF as a whole, which is 19.6–22.9 kg/m2 in boys aged 17 and 18.7–22.3 kg/m2 in girls. At the same time, there is an influence of socio-economic factors. The analysis of the regional features of BMI formation in children and adolescents aged 7–17 years has shown that BMI has a higher value, the lower the place of the subject of the RF in terms of gross regional product.
Received: 2024-08-21
Published online: 2025-03-28
DOI: 10.24075/rbh.2025.123
Comments 0
VIEWS 1023
Original research The state of health of 1st-, 2nd-, and 3rd-year students of a medical university
Shestera AA, Trankovskaya LV
Today, preserving the health of medical students, who constitute the labor pool for Russia's healthcare system, is a strategically important task for both the state and society. The purpose of this work was to investigate the status of health of 1st-, 2nd-, and 3rd-year students of Pacific State Medical University of the Ministry of Health of the Russian Federation. The students underwent a comprehensive examination at the beginning and at the end of the academic year. All in all, we examined 698 people in 2022 and 516 people in 2023. The examination was physical, focusing on the functional state of the cardiorespiratory system, and also assessed the participants' mental health. Primary medical documentation was used as a source of information to assess the incidence of temporary disability and chronic non-communicable diseases of students. Data comparison was done using nonparametric statistical methods. The differences were considered statistically significant at p < 0.05. We revealed a downward trend for the students' health indicators, which confirms their allocation into health status groups. At the beginning of the academic year, the 1s group was the largest, and by its end, the share of those reallocated to the 3rd group was significant, with the group including 33.1% of make participants and 36.8% of female participants.  This study substantiates the need for continued monitoring of the health status of students. The resulting data enable assessment of the students' health status and identification of priority preventive measures to be developed to preserve their health.
Received: 2024-10-29
Published online: 2025-03-26
DOI: 10.24075/rbh.2025.122
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Original research Sleep disorders in primary school children associated with use of various types of digital devices
Khramtsov PI, Kurgansky AM, Berezina NO, Chekalova SA, Antonova EV
Health of children and adolescents largely depends on the quality of their sleep. However, the effect of digital devices and screen time on thereon have not been studied thoroughly. This study aimed to investigate the influence of digital devices on the sleep quality of primary school children. We surveyed 333 parents of children aged 7–10 years. The questionnaire included questions about the types of digital devices used by children, and frequency and duration of use daily and weekly use. We studied the specifics and quality of sleep of children. It was found that using a laptop for more than an hour a day increases the risk of sleep disorders (RR = 1.87; 95% CI: 1.37–2.54; EF = 46%). Children using a computer every day run a higher risk of nightmares (RR = 4.7; 95% CI: 1.49–15.11; EF = 79%). Neither TV, nor mobile phones were shown to produce such effects. The study has revealed that the type of the device and the patterns of its use (on both daily and weekly levels) are factors in the development of sleep disorders.
Received: 2023-12-07
Published online: 2024-12-25
DOI: 10.24075/rbh.2024.115
Comments 0
VIEWS 1148
Original research Analysis of body mass index formation in children and adolescents of the Russian Federation
Levushkin SP, Milushkina OYu, Skoblina NA, Markelova SV, Tatarinchik AA, Ivanov MS
To prevent health problems in pediatric population, the Russian Federation (RF) is implementing the Complex of measures to combat obesity in children under 18 years of age, approved on  December 1, 2023, No. 18824-P12-TG. The study aimed to consider body mass index (BMI) formation in Russian children and adolescents in the regional aspect. As part of the all-Russian monitoring of the physical development of children and adolescents in 2021–2024, BMI of 258,611 boys and 252,629 girls living in 50 constituent entities of the RF was studied. Big data analysis has shown that in most regions there is a harmonious development of the child population and the indicators fit into the BMI 25th–75th centile for the RF as a whole, which is 19.6–22.9 kg/m2 in boys aged 17 and 18.7–22.3 kg/m2 in girls. At the same time, there is an influence of socio-economic factors. The analysis of the regional features of BMI formation in children and adolescents aged 7–17 years has shown that BMI has a higher value, the lower the place of the subject of the RF in terms of gross regional product.
Received: 2024-08-21
Published online: 2025-03-28
DOI: 10.24075/rbh.2025.123
Comments 0
VIEWS 1023
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