Today, preserving the health of medical students, who constitute the labor pool for Russia's healthcare system, is a strategically important task for both the state and society. The purpose of this work was to investigate the status of health of 1st-, 2nd-, and 3rd-year students of Pacific State Medical University of the Ministry of Health of the Russian Federation. The students underwent a comprehensive examination at the beginning and at the end of the academic year. All in all, we examined 698 people in 2022 and 516 people in 2023. The examination was physical, focusing on the functional state of the cardiorespiratory system, and also assessed the participants' mental health. Primary medical documentation was used as a source of information to assess the incidence of temporary disability and chronic non-communicable diseases of students. Data comparison was done using nonparametric statistical methods. The differences were considered statistically significant at p < 0.05. We revealed a downward trend for the students' health indicators, which confirms their allocation into health status groups. At the beginning of the academic year, the 1s group was the largest, and by its end, the share of those reallocated to the 3rd group was significant, with the group including 33.1% of make participants and 36.8% of female participants.  This study substantiates the need for continued monitoring of the health status of students. The resulting data enable assessment of the students' health status and identification of priority preventive measures to be developed to preserve their health.