Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

REVIEW

Molecular mechanisms underlying proteomic profile changes induced by combined exposure to airborne pollutants causing oxidative stress

About authors

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Perm, Russia

Correspondence should be addressed: Ekaterina V. Peskova
Monastyrskaya, 82, Perm, 614045, Russia; ur.ksircf@avoksep

About paper

Acknowledgement: the author expresses gratitude to Nina Vladimirovna Zaitseva, Academician of the Russian Academy of Sciences, Doctor of Medicine, Professor, Honored Scientist of the Russian Federation, Scientific Director at Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, and Marina Aleksandrovna Zemlyanova, Doctor of Medicine, Professor, Head of the Department of Biochemical and Cytogenetic Diagnostic Methods of Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, for their assistance in preparing this work.

Received: 2026-07-07 Accepted: 2026-10-02 Published online: 2026-11-05
|
  1. Rakitskij VN, Kuzmin SV, Avaliani SL, Shashina TA, Dodina NS, Kislitsin VA. Sovremennye vyzovy i puti sovershenstvovaniya otsenki i upravleniya riskami zdorovʹyu naseleniya. Analiz riska zdorovʹyu. 2020; (3): 23−9 (in Rus.). DOI: 10.21668/health.risk/2020.3.03.
  2. Roslyj OF, Gurvich VB, Plotko EG, Kuzmin SV, Fedoruk AA, Roslaya NA, et al. Aktualʹnye voprosy gigieny v alyuminievoj promyshlennosti Rossii. Meditsina truda i promyshlennaya ekologiya. 2012; (11): 8−12 (in Rus.).
  3. Zajtseva NV, Zemlyanova MA, Peskova EV. Proteomnyj kod v gigiene. Permʹ: Izdatelʹskij dom "Tipografiya kuptsa Tarasova", 2026; 296 p. (in Rus.).
  4. Zemlyanova MA, Zajtseva NV, Koldibekova YuV, Peskova EV, Bulatova NI. Sozdanie bioinformatsionnoj matritsy molekulyarnykh markerov dlya prognozirovaniya risk-assotsiirovannykh narushenij zdorovʹya. Analiz riska zdorovʹyu. 2022; (2): 174–84 (in Rus.). DOI: 10.21668/health.risk/2022.2.16.
  5. Wu H, Eckhardt CM, Baccarelli AA. Molecular mechanisms of environmental exposures and human disease. Nat Rev Genet. 2023; 24 (5): 332−44. DOI: 10.1038/s41576-022-00569-3.
  6. Zajtseva NV, Zemlyanova MA, Peskova EV. Prognoz veroyatnykh negativnykh effektov, initsiirovannykh transformatsiej proteomnogo profilya plazmy krovi cheloveka pri kombinirovannom vozdejstvii khimicheskikh veshchestv. Gigiena i sanitariya. 2024; 103 (5): 407−15 (in Rus.). DOI: 10.47470/0016-9900-2024-103-5-407-415.
  7. Zemlyanova MA, Zajtseva NV, Koldibekova YuV, Perezhogin AN, Stepankov MS, Bulatova NI. Vyyavlenie omik-markerov negativnykh effektov, assotsiirovannykh s aerogennym kombinirovannym vozdejstviem soedinenij alyuminiya i ftora. Analiz riska zdorovʹyu. 2022; (1): 123–32 (in Rus.). DOI: 10.21668/health.risk/2022.1.13.
  8. Zajtseva NV, Zemlyanova MA, Dolgikh OV. Genomnye, transkriptomnye i proteomnye tekhnologii kak sovremennyj instrument diagnostiki narushenij zdorovʹya, assotsiirovannykh s vozdejstviem faktorov okruzhayushchej sredy. Gigiena i sanitariya. 2020; 99 (1): 6−12 (in Rus.). DOI: 10.47470/0016-9900-2020-99-1-6-12.
  9. Han S, Lemire J, Appanna VP, Auger C, Castonguay Z, Appanna VD. How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale. Cell Biol Toxicol. 2013; 29 (2): 75−84. DOI: 10.1007/s10565-013-9239-0.
  10. Sadauskiene I, Liekis A, Staneviciene I, Naginiene R, Ivanov L. Effects of long-term supplementation with aluminum or selenium on the activities of antioxidant enzymes in mouse brain and liver. Catalysts. 2020; 10 (5): 585. DOI: 10.3390/catal10050585.
  11. Gaur A, Nayak P, Ghosh S, Sengupta T, Sakthivadivel V. Aluminum as a possible cause toward dyslipidemia. Indian J Occup Environ Med. 2023; 27 (2): 112−9. DOI: 10.4103/ijoem.ijoem_349_21.
  12. Yang X, Yu K, Wang H, Zhang H, Bai C, Song M, et al. Bone impairment caused by AlCl3 is associated with activation of the JNK apoptotic pathway mediated by oxidative stress. Food Chem Toxicol. 2018; 116 (Pt B): 307−14. DOI: 10.1016/j.fct.2018.04.057.
  13. Makhdoomi S, Ariafar S, Mirzaei F, Mohammadi M. Aluminum neurotoxicity and autophagy: a mechanistic view. Neurol Res. 2023; 45 (3): 216−25. DOI: 10.1080/01616412.2022.2132727.
  14. Zhukova AG, Mikhajlova NN, Kazitskaya AS, Alekhina DA. Sovremennye predstavleniya o molekulyarnykh mekhanizmakh fiziologicheskogo i toksicheskogo dejstviya soedinenij ftora na organizm. Meditsina v Kuzbasse. 2017; 16 (3): 4−11 (in Rus.).
  15. Oka S, Li X, Zhang F, Taguchi C, Tewari N, Kim IS, et al. Oral toxicity to high level sodium fluoride causes impairment of autophagy. J Physiol Pharmacol. 2020; 71 (5). DOI: 10.26402/jpp.2020.5.14.
  16. Gutiérrez-Salinas J, García-Ortíz L, Morales González JA, Hernández-Rodríguez S, Ramírez-García S, Núñez-Ramos NR, et al. In vitro effect of sodium fluoride on malondialdehyde concentration and on superoxide dismutase, catalase, and glutathione peroxidase in human erythrocytes. ScientificWorldJournal. 2013; (2013): 864718. DOI: 10.1155/2013/864718.
  17. Aulestia FJ, Groeling J, Bomfim GHS, Costiniti V, Manikandan V, Chaloemtoem A, et al. Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells. Sci Signal. 2020; 13 (619): eaay0086. DOI: 10.1126/scisignal.aay0086.
  18. Suzuki M, Bandoski C, Bartlett JD. Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling. Free Radic Biol Med. 2015; (89): 369−78. DOI: 10.1016/j.freeradbiomed.2015.08.015.
  19. Umarani V, Muvvala S, Ramesh A, Lakshmi BV, Sravanthi N. Rutin potentially attenuates fluoride-induced oxidative stress-mediated cardiotoxicity, blood toxicity and dyslipidemia in rats. Toxicol Mech Methods. 2015; 25 (2): 143−9. DOI: 10.3109/15376516.2014.1003359.
  20. Wang H, Yang Z, Zhou B, Gao H, Yan X, Wang J. Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level. Toxicol Ind Health. 2009; 25 (1): 49−57. DOI: 10.1177/0748233709102720.
  21. Lou W, Zhang MD, Chen Q, Bai TY, Hu YX, Gao F, et al. Molecular mechanism of benzo[a]pyrene regulating lipid metabolism via aryl hydrocarbon receptor. Lipids Health Dis. 2022; 21 (1): 13. DOI: 10.1186/s12944-022-01627-9.
  22. Verma N, Pink M, Rettenmeier AW, Schmitz-Spanke S. Review on proteomic analyses of benzo[a]pyrene toxicity. Proteomics. 2012; 12 (11): 1731−55. DOI: 10.1002/pmic.201100466. PMID: 22623321.
  23. Xu H, Lauer FT, Liu KJ, Hudson LG, Burchiel SW. Editor's highlight: interactive genotoxicity induced by environmentally relevant concentrations of benzo(a)pyrene metabolites and arsenite in mouse thymus cells. Toxicol Sci. 2016; 154 (1): 153−61. DOI: 10.1093/toxsci/kfw151.
  24. Allmann S, Mayer L, Olma J, Kaina B, Hofmann TG, Tomicic MT, et al. Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence. Nucleic Acids Res. 2020; 48 (21): 12085−101. DOI: 10.1093/nar/gkaa965.
  25. Peskova EV. Eksperimentalʹnaya otsenka kombinirovannogo dejstviya khimicheskikh veshchestv na osnove kvantifikatsii belkov plazmy krovi. Gigiena i sanitariya. 2025; 104 (5): 648−54 (in Rus.). DOI: 10.47470/0016-9900-2025-104-5-648-654.
  26. Liu D, Zhao Y, Qi Y, Gao Y, Tu D, Wang Y, et al. Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice. J Neuroinflammation. 2020; 17 (1): 258. DOI: 10.1186/s12974-020-01925-y.
  27. McLachlan DRC, Bergeron C, Alexandrov PN, Walsh WJ, Pogue AI, Percy ME, et al. Aluminum in neurological and neurodegenerative disease. Mol Neurobiol. 2019; 56 (2): 1531−8. DOI: 10.1007/s12035-018-1441-x. Retraction in: Mol Neurobiol. 2020; 57 (3): 1779. DOI: 10.1007/s12035-020-01883-9.
  28. Jinzhu Y, Qinli Z, Jin Y, Pan K, Jianjun H, Qiao N. Aluminum and benzo[a]pyrene co-operate to induce neuronal apoptosis in vitro. J Toxicol Sci. 2015; 40 (3): 365−73. DOI: 10.2131/jts.40.365.
  29. Mintel MV, Zemlyanova MA, Zhdanova-Zaplesvichko IG. Nekotorye aspekty sovmestnogo dejstviya alyuminiya i ftora na organizm cheloveka (obzor literatury). Ekologiya cheloveka. 2018; 25 (9): 12−7 (in Rus.). DOI: 10.33396/1728-0869-2018-9-12-17.
  30. Guo X, Cai R, Wu S, He Y, Sun G. Combined effect of fluoride and aluminum on the expression of Runx2 and Osterix mRNA in MC3T3-E1 cells. Wei Sheng Yan Jiu. 2011; 40 (2): 164−6.
  31. Park B, Yang YM, Choi BJ, Kim MS, Shin DM. Activation of G proteins by aluminum fluoride enhances RANKL-mediated osteoclastogenesis. Korean J Physiol Pharmacol. 2013; 17 (5): 427−33. DOI: 10.4196/kjpp.2013.17.5.427.
  32. Borosky GL, Laali KK. Oxidized metabolites from benzo[a]pyrene, benzo[e]pyrene, and aza-benzo[a]pyrenes. A computational study of their carbocations formed by epoxide ring opening reactions. Org Biomol Chem. 2007; 5 (14): 2234−42. DOI: 10.1039/b704090c.