Drinking water occupies one of the leading places among environmental factors responsible for shaping public health, so providing sanitary-and-epidemiologic wellbeing of the population cannot be considered separately from solving the hygienic problem of water supply. The study aimed to provide comparative hygienic characteristics of the quality of drinking water from the Ryazan centralized water supply system based on organoleptic indicators. Comparative assessment of the quality of drinking water was performed based on the analysis of the data of the years of research for the years 2017–2022. We performed analysis of the long-term average annual values of odor at 20 ºС and 60 ºС, taste, color and turbidity, share of samples non-compliant with the hygienic standards, over time. Inidicators were also assessed based on the season of the year and territorial belonging. The average indicator values were compared using analysis of variance; pairwise comparison involved the use of the Scheffe and Tamhane tests considering the Levene’s test results. Confidence intervals of the relative indicators were determined based on the Wilson score. The long-term average annual values of organoleptic indicators of the quality of drinking water in Ryazan are compliant with SanPiN 1.2.3685-21. A small number of samples had odor, taste, and color exceeding the hygienic standards. Turbidity that was non-compliant with the hygienic requirements in 2.2% of samples and reached the maximum value of 16.4 mg/L (kaolin) should be considered the most challenging indicator of the quality of test drinking water.