Excess weight and obesity detected in adolescence are likely to be detected in adulthood, which increases the risk of cardiovascular disorders. The study was aimed to assess the features of cardiovascular system parameters in adolescent males considering their body mass index (BMI). For this purpose a total of 208 adolescent males aged 15–16 were surveyed. The major indicators of physical development and cardiovascular system function were evaluated by standard method. BMI was calculated, based on which three groups were distinguished: underweight adolescents, adolescents with normal and excess body weight. It was found that 23% of subjects were underweight, 62% had normal body weight, and excess body weight was reported in 15% of adolescents. It has been shown that the growth of strain on the cardiovascular system from the group of underweight adolescents to the group with excess weight is observed (4, 16, and 37%, respectively), which is confirmed by the correlation analysis results. The findings suggest the less effective cardiovascular system functioning mode in overweight adolescents compared to other assessed groups. The data obtained can be used to develop the guidelines on managing excess body weigth in the group of individuals being through the adolescent ontogeny period as a target group for health promotion and applying preventive measures.