The paper provides the analysis of the research and practical work done at the Department of Hygiene, Pirogov Russian National Research Medical University, for the period between 2018 and 2023 aimed to determine the today’s directions of the Department and demonstrate their relevance, scientific and practical significance; prospective directions of further research are defined. Statistical data processing was performed using the Statistica 13 PL software and the tag (word) cloud service. Staff of the Department did extensive educational and methodological, organizational and methodological, expert and consulting, research work (paragraphs 1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12 of the academic passport for the specialty 3.2.1. “Hygiene”); a total of 10 textbooks and three toolkits, three guidelines, two software products, one patent for invention and 39 database certificates, 11 collective monographs were published; two hygienic standards were approved; the activity outcomes were presented during 95 scientific and practical events, including that with international involvement. A total of 150 articles were published: 46 in the journals indexed in international databases (Scopus, Web of Science), 58 in the journals indexed by HAC under the Ministry of Education and Science of the Russian Federation, one in the Nature journal. Two candidate and two doctoral theses on the specialty 3.2.1. “Hygiene” were prepared and defended. The activity outcomes provided helped to address the hygienic challenges currently faced by professional community to achieve the national goals of the Russian Federation in the fields of demography, public health and digitalization.