Funding: the study was conducted at the expense of budget financing of the “Arctic” Research Center, Far Eastern Branch RAS, under the theme “Study of Intersystem and Intrasystem Response Mechanisms in Formation of the “Northern Type” Human Body Functional Adaptive Reserves at Different Ontogeny Stages in Individuals Living in Uncomfortable and Extreme Environment Involving Determination of Integral Informative Health Indices” (ID АААА-А21-121010690002-2).

Author contribution: Khorosheva IV — study concept and design, data acquisition and processing, manuscript writing and editing.

Compliance with ethical standards: the study was performed in accordance with the ethical principles for medical research involving human subjects enshrined in the Declaration of Helsinki (2013); the study protocol was approved by the Ethics Committee of the “Arctic” Research Center, Far Eastern Branch, Russian Academy of Sciences (report № 002/021 of 26 November 2021).