ISSN Print 2713-0878
ISSN Online 2713-0886
BIOMEDICAL JOURNAL OF ERMC EASTERN EUROPEAN
Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
METHOD
Experimental assessment of the effect of antipsychotics by wedge-shaped dehydration
About authors
Pirogov Russian National Research Medical University (Pirogov University), Moscow, Russia
Correspondence should be addressed: Elena D. Drugova
Ostrovityanov, 1, Moscow, 117513, Russia; ur.xednay@9002anele.avogurd
About paper
Author contribution: Drugova ED ― material collection and processing, manuscript writing, statistical analysis; Sheina NI ― research concept and design, manuscript writing, editing; Korolik VV ― research concept, manuscript editing.
Compliance with ethical standards: animal keeping and handling during the experiment were compliant with the principles of Good Laboratory Practice (GLP) and GOST 33044―2014 “Principles of Good Laboratory Practice”. The study was approved by the Ethics Committee of the Pirogov Russian National Research Medical University (protocol No. 9 dated September 20, 2023. Blood collection from the volunteers, who had had submitted the informed consent, was regulated by GOST R 59778―2021 “Procedure of Venous and Capillary Blood Sampling Procedure for Laboratory Testing”.
Received: 2025-11-28
Accepted: 2026-05-17
Published online: 2026-09-26
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Fig. 1. Serum facies structure under physiologically normal conditions in rats and humans. А. Rat. B. Human
Fig. 2. Reduction in the width of the serum facies central zone in rats (general view) one hour after the administration of haloperidol (А) and aminazine (B) to rats. C. Control group, 12.5× magnification
Fig. 3. Rope-like structures in the rat blood serum facies 4 h after the intragastric administration of haloperidol (А) and aminazine (B) to rats, 63× magnification
Fig. 4. Spiral cracks in the rat blood serum facies 24 ч h after the administration of haloperidol (А) and aminazine (B) to rats, 63× magnification
Fig. 5. Rope-like structures in blood serum facies 24 h after the haloperidol administration to the rat (А) and after the haloperidol intake in human (B) — circled in red, 63× magnification
Table 1. Changes in the structural markers of blood serum facies 1, 4, and 24 h after antipsychotic administration
Note: * — significant differences from the control group based on the Dunnett's test (p ≤ 0.05); ** — significant differences from the groups of animals administered antipsychotics based on the Student’s t-test (p ≤ 0.05).
Table 2. Summary table of antipsychotic markers and effects in rats at various observation time points
Note: + — effect; – — no effect
