There are many hazards a pathologist is exposed to professionally, including biological (pathogens), chemical (preservatives, reagents), physical (radiation, noise) factors, psycho-emotional stress, and ergonomic risks. Historically, the standardization of these factors and risks has lagged significantly behind practice. The digitalization of pathology (digital microscopy, telemedicine) mitigates some traditional hazards but generates new risks: visual stress, sedentary working conditions, exposure to electromagnetic fields, and psycho-emotional stress from using digital platforms. The history of standardization reflects progress in understanding the unique risks of the profession and the value of medical workers' health. Technological advances necessitate the continued updating of regulations. Thus far, too few studies have been conducted on the evolution of adverse factors and their sanitary and hygienic standardization in the work of pathologists. This review analyzes the development of a system of professional sanitary and hygienic standards for pathologists in Russia.