To make managerial decisions on the prevention of occupational and morbidity, it is necessary to track how health status of the working population depends on the degree of occupational risk. This study aimed to identify the features of the long-term dynamics of occupational morbidity at the level of production facilities (various industries) in the Voronezh region. The assessment of the level of occupational pathology was based on the type of economic activity, the administrative-territorial affiliation of the region's constituent, nosological forms, and factors of the workflow. We have identified the main patterns of occupational morbidity dynamics; in 2021−2022, its growth was primarily driven by the biological factor. With the companies/establishments being unready to face the new occupation-related risk factors, there emerge previously unregistered occupational morbidities that largely incapacitate the affected individuals.