Solving the problems of ensuring long and active life of all Russians, regardless of their place of residence, requires the development and implementation of digital preventive medicine technologies. It is noted that it is necessary to develop and implement health risk monitoring consistent with the digital technology development level, principle of data-driven management, and conceptual provisions of the disease prediction and prevention, personalized and participatory nature of medical care to create the human health shaping, maintenance, and preservation digital platform. The paper provides the rationale for the fact that the block (cascade) diagram of occupational health changes in aviation, the use of which as part of the digital platform to be created requires enlargement of the set of blocks of the health risk minimization cascade and the cascade of the risk factor effect minimization aimed to consider all the health risk minimization potentialities, as well as to develop methodological support of the risk factor dose and health risk calculation aimed to cover the maximum number of social and occupational population groups, meets these requirements.