Obesity is a global epidemic of the 21st century and a core component in the development of nutrition-related diseases. In the Russian Federation (RF), more than 60% of the adult population is overweight or obese, which necessitates designing and implementing new prevention strategies. This study aimed to provide a scientific basis for the role of personalized dietary interventions and educational technologies in preventing obesity-related complications. We reviewed papers from PubMed and eLIBRARY databases (2020-2026) found by keywords "obesity," "nutrition," "education," "prevention". The analysis showed that the effectiveness of the traditional approaches to diet therapy is insufficient. It was established that the key to successful prevention is extended diagnostics providing data on the individual metabolic phenotypes. Healthy Nutrition educational cluster and digital components of the NIAP system (research-based educational and analytical platform) are important tools in increasing obesity-related public awareness and professional training of medical specialists. Effective personalized prevention of obesity complications requires concurrent realization of three interrelated initiatives: diet correction based on instrumental diagnostics; adoption of educational technologies for doctors and patients; and reinforcement of sanitary and epidemiological surveillance measures. The proposed multilevel approach, which integrates hygiene-related measures and modern digital tools, enables a reduction in the prevalence of obesity and the achievement of strategic public health-saving goals in the Russian population.