Author contribution: Gaydina TA — data acquisition and analysis, statistical processing, manuscript writing; Milushkina OYu — study concept, manuscript writing; Skoblina NA — manuscript writing and editing; Ievleva OV — literature review, collection and analysis of literary sources, analysis of regulatory and methodological documents; All authors confirm that their authorship complies with the international ICMJE criteria (all authors made a significant contribution to the development of the concept, conduct of the study and preparation of the article, read and approved the final version before publishing).

Compliance with ethical standards: the study was approved by the Ethics Committees of the Pirogov Russian National Research Medical University (protocol No. 244 dated 21 October 2024) and the Federal Center for Brain and Neurotechnology of FMBA of Russia (protocol No. 02/17-02-25 dated 17 February 2025). The study was compliant with the standards of Good Clinical Practice and principles of the Declaration of Helsinki.