2024 / 02

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DOI: 10.24075/rbh.2024.096

ORIGINAL RESEARCH

Comparative analysis of the cytogenetic status of pregnant women residing in the territories of radioactive, chemical and combined contamination

Domakhina AS1, Korsakov AV2, Troshin VP1, Milushkina OYu2, Pivovarov YuP2, Korolik VV2
About authors

1 Bryansk State Technical University, Bryansk

2 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Alexandra S. Domakhina
Bulvar 50 let Oktyabrya, 7, Bryansk, 241035, Russia; ur.xednay@ahsasanihamod

About paper

Acknowledgement: the authors would like to express particular gratitude to O.M. Gavrilova, obstetrician-gynecologist at the Bryansk City Hospital № 1, for assistance in biomaterial collection.

Author contribution: Domakhina AS — search for literature, statistical analysis, manuscript writing, manuscript editing and discussion; Korsakov AV — literature review, study concept and design, interpretation of the results, approval of the final version of the article; Troshin VP — data analysis and interpretation, manuscript writing, editing and discussion; Milushkina OYu, Pivovarov YuP, Korolik VV — data analysis and interpretation, manuscript editing and discussion.

Compliance with ethical standards: the informed consent to collection of biomaterial during screening and clinical data processing was obtained from all patients.

Received: 2024-02-05 Accepted: 2024-04-10 Published online: 2024-06-25
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Fig. Microphotographs of the cytogenetic alterations, indicators of proliferation and destruction of the nucleus in the vaginal epithelium of pregnant women aged 28–33 years (Quik stain, 1000× magnification)
Table 1. Levels of chemical and radioactive contamination of the environment in the studied groups of towns and districts of the Bryansk Region (2010–2019)
Table 2. Comparative analysis of the cytogenetic alterations, indicators of proliferation and destruction of the nucleus in the vaginal epithelium of pregnant women aged 28–33 years living in various environmental conditions (per 1000 cells, ‰)
Note: * — the differences are considered significant at р < 0.05; — the differences are considered significant at р < 0.01; *— the differences are considered significant at р < 0.001; n/d — the differences are considered non-significant atр > 0.05.