The allergic diseases, the major role in etiology of which is played by allergens present in ambient air, are common. To develop practical guidelines on prevention of allergic rhinitis as the most prevalent disorder in the structure of allergy, it is necessary to estimate all the conditions, both negatively and positively affecting this disorder. The study was aimed to assess factors affecting the incidence, detection, and registration of cases of allergic rhinitis in the Voronezh Region. The report forms № 12 and № 30 provided substantive inputs to the study, along with the laboratory test data provided by private clinics and the social and hygienic monitoring data. Epidemiological analysis was performed by retrospective method; the territories were ranked by various indicators; the correlation analysis method was applied. We determined the incidence rates and the districts at high risk of allergic rhinitis (pollinosis) in all population groups for the period 2012–2021. We determined the structure of aeroallergens identified in private healthcare institutions, assessed the staffing levels of allergists in the public institutions of the Voronezh Region, and identified significant environmental factors. The identified features of the prevalence, diagnosis, and registration of allergic rhinitis in the Voronezh Region can be used to improve preventive measures targeting this allergic disorder.