Author contribution: Makarova IO — conducting experiments and collecting data/evidence, analyzing and interpreting the data obtained; taking responsibility for all aspects of the paper, the integrity of all parts of the paper and its final version; applying statistical, mathematical, computational or other formal methods to analyze and synthesize research data.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Burdenko Voronezh State Medical University (protocol № 7 dated 8 November 2021). All study participants submitted the informed consent to personal data processing.