The quality of drinking water is one of the key factors defining the health of the population. The risk-based approach is one of the most effective drinking water quality assessment and control tools. This study aimed to make a comparative integral assessment of the quality of drinking water from a centralized water supply system in residential areas of Ryazan based on chemical safety indicators. We have considered organoleptic, non-carcinogenic and carcinogenic risks, and compiled an integral assessment based on MR 2.1.4.0032-11. The drinking water quality monitoring data used for the assessment came from the Center for Hygiene and Epidemiology in the Ryazan Region, and covered years 2017 through 2022. Identifying the hazards, we relied on the above-norm spikes in drinking water quality indicator values registered during the specified period. The maximum figures used to calculate the organoleptic risks had 98% confidence interval, while that for the data enabling non-carcinogenic and carcinogenic risk assessments was 95% (nonthreshold models), the said data reflecting the average long-term concentrations. The uncertainties inherent in the risk assessment stem from the limited list of indicators controlled in drinking water. In all residential districts of the city of Ryazan, the integral indicator (II) of the level of hazard of drinking water from the centralized water supply system exceeds the acceptable values, with the said level being the highest in Solotcha (II = 8.8) and Kanishchevo (II = 5.6). In all districts of the city, the indicator is largely shaped by the high organoleptic risk, which points to the need for respective mitigation measures.