Currently, studying the quality and style of life of students is an urgent task due to the need to improve the demographic situation and increase the intellectual potential of the country. This article presents an analysis of the quality of life of medical and humanitarian specialties students of Voronezh universities. We sought to compare these parameters based on the data collected with the help of the SF-36 survey and the HPLP (Health-Promoting Lifestyle Profile) questionnaire. The study involved 262 students of the Burdenko Voronezh State Medical University, Voronezh State University and Voronezh branch of Plekhanov Russian University of Economics aged 18–25 years. We revealed significant differences between educational institutions in a number of key indicators, which highlights the importance of factoring in the specifics of the educational environment when designing health preservation programs for students. According to the results of the survey (SF-36), humanitarian specialties students self-assessed their health better then future medical professionals (median values 70 points vs. 65 points, respectively), same as physical activity and nutrition, as shown by the HPLP questionnaire (20.5 points vs. 18 points and 24 points vs. 23 points, respectively). The resulting data revealing the differences in the quality and lifestyle of students can be used in the development of health and wellbeing improvement recommendations for students, and in the design of comprehensive physical and mental health preservation programs.