The article deals with the issues of health in children and adolescents aged 7–17 years. The objective of this study is to analyze health experience in school-age children and adolescents based on regular medical check-up results. According to regular medical check-up results, 15,192 schoolchildren were examined in 2015, including 12,649 children aged 7–14 years and 2,543 children aged 15–17 years. In 2020, health of 18,708 schoolchildren was assessed, including 14,861 children aged 7 to14 years and 3,847 children aged 15 to 17 years. The authors analyze dynamics of distribution of children into health groups, and age-related incidence of school- related diseases. In children and adolescents of different age, eye disorders occupy first place in the rank of prevalent school- related diseases; the events are followed by musculoskeletal diseases, nervous and GIT diseases, progressing with age, including scoliosis. Percentage of healthy children without the signs of a school- related abnormality at school is reducing. In the majority of cases, pathological abnormalities are found in 15–17-year-old adolescents.