The study was aimed to compare physical developmental characteristics in children and adolescents aged 7–18 living in Kursk for the years 2000–2001 and 2019–2020. The study was carried out in general educational institutions located in different urban areas of Kursk in    2000–2001 and 2019–2020. The standard anthropometric measurements, instruments and statistical methods were used. A total of 20,083 school-age children and adolescents were examined. The inclusion criteria were as follows: school-age children and adolescents staying at the educational institution at the time of the study, informed consent form properly completed, anthropometric measurements correctly performed. Statistical processing of the results was carried out using the Statistica 10.0 software package. The 20-year monitoring of physical development characteristics performed in school-age children and adolescents living in Kursk revealed the significant increase in height and body weight in all age and gender groups. The harmonious body acceleration manifestations associated with the muscle strength increase were observed in the context of sociomedical progress in Kursk.